Quercetin is a naturally occurring flavonoid found in many fruits, vegetables, and grains. It has attracted considerable interest in the fields of longevity, aging, and health due to its potential benefits. Although the exact mechanisms are not yet fully understood, multiple studies have suggested that quercetin may have various positive effects on human health. Some of the potential benefits of quercetin include:
- Antioxidant properties: Quercetin is a potent antioxidant that can neutralize free radicals, which are unstable molecules that can cause oxidative stress and damage to cells. Oxidative stress has been implicated in the aging process and the development of many age-related diseases (K. R. Martin et al., 2019).
- Anti-inflammatory effects: Inflammation is a natural response of the immune system to injury or infection but can become chronic and contribute to aging and various diseases. Quercetin has demonstrated anti-inflammatory properties by inhibiting the production of inflammatory cytokines and suppressing the activation of nuclear factor-kappa B (NF-κB) (Min Y. et al., 2020).
- Cardiovascular benefits: Quercetin has been found to reduce blood pressure and improve endothelial function, both of which are important for maintaining good cardiovascular health (S. Serban et al., 2016). Additionally, it has been shown to reduce the oxidation of low-density lipoprotein (LDL) cholesterol, which may help prevent the development of atherosclerosis (K. R. Martin et al., 2019).
- Neuroprotective effects: Studies have indicated that quercetin may help protect brain cells from oxidative stress and inflammation, potentially reducing the risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s (J. P. Spencer et al., 2012).
- Anti-cancer properties: Some research suggests that quercetin may have anti-cancer effects by inhibiting the growth and proliferation of cancer cells, inducing apoptosis (cell death), and suppressing angiogenesis (the formation of new blood vessels to supply tumors) (A. G. Russo et al., 2012).
- Anti-aging effects: Quercetin has been shown to activate sirtuins, a class of proteins that play a crucial role in the regulation of aging and cellular health. Sirtuin activation has been associated with increased longevity and a delay in the onset of age-related diseases (K. R. Martin et al., 2019).
- Improved exercise performance and recovery: Some studies suggest that quercetin supplementation may enhance endurance, exercise performance, and recovery by reducing oxidative stress and inflammation in muscles (J. M. Davis et al., 2009).